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Murdoch is a mixed-use suburb with residential and institutional sectors. Bound by South Street in the north and west and the Kwinana Freeway in the east, Murdoch's most significant development occurred during the 1970s and 1980s. The population continued to increase in the early 1990s as an influx of medium-density housing was added to the area.
Murdoch is most notably associated with its various health and education institutions. Murdoch University and Challenger Institute of Technology are two major educational facilities that services students from all over the Perth-metro area, while two major hospitals - privately owned St John of God Murdoch Hospital and government-operated Fiona Stanley Hospital - service much of Western Australia's medical requirements. Parks and reserves also feature in the suburb, as does the Murdoch University Sports Ground and the Murdoch Train Station.